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                  默沙東艾滋新藥III期臨床成功

                  2017/02/24

                  來源:藥研發              時間:2017.2.17

                  默沙東(MSD)宣布其非核苷逆轉錄酶抑制劑(NNRTI)doravirine(MK-1439)治療HIV-1感染的一項關鍵性III期臨床試驗達到了主要研究終點:部分受試者在經過48周治療后HIV-1 RNA達到低于50個拷貝/毫升的水平,表明在治療HIV-1感染的初治(未經治療)成年患者時,每天一次的doravirine對比每日一次的ritonavir-boosted darunavir(DRV+r)的非劣效性。此外,次要終點顯示,與DRV+r治療組相比,經doravirine治療的患者的空腹低密度脂蛋白膽固醇(LDL-C)水平獲得了統計學意義上的顯著降低。該結果提供了doravirine作為治療初治HIV-1患者的潛在治療選擇的有效性和安全性的可靠證據。


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